CDS: tpi1


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General Information

Name

tpi1

Systematic Name

SPCC24B10.21

Gene Synonyms

tpi

Status

experimentally characterised (or published)

Product

triosephosphate isomerase

Type

CDS

Sequence

DNA and Protein

Location

Chromosome

Contig Location

939945..940694 (Unspliced length: 750 bp)

Exons

939945..940694 (Spliced length: 750 bp)

Region download and display (in Artemis)

Genome Browser

Context Map:
Context Feature Map

SPCC24B10.15 SPCC24B10.16c emp24 SPCC24B10.18 SPCC24B10.19c SPNCRNA.476 SPCC24B10.20 >tpi1< pog1 SPCPB16A4.02c SPCTRNAASN.05 ade10 SPNCRNA.477 trm8

Curation

Term	Db xref/URL	Other genes annotated to this term
disease associated, hemolytic anemia		(1 Other)
orthologous to S. cerevisiae YDR050C		(0 Others)
conserved in Eukaryotes		(4113 Others)
conserved in Bacteria		(830 Others)
conserved in Metazoa		(3558 Others)
conserved in Vertebrates		(3556 Others)
conserved in Fungi		(4163 Others)
predominantly uniformly single copy (one to one)		(2867 Others)
modification, phosphorylated	PMID:18257517	(695 Others)

Predicted Peptide Properties

Mass

27.2 kDa	Amino acids	249
pH 7.0	Charge	1.5

Isoelectric point

Signal Peptide

Not found

Transmembrane Domains

0 found

GPI Anchor

Not found

Gene Ontology Annotation

Term (browse Amigo)	Qualifier	Evidence	Other genes annotated to this term
Biological Process
gluconeogenesis		IC (PMID:17072883) from GO:0004807	14 others
glycolysis		IC (PMID:17072883) from GO:0004807	18 others
pentose-phosphate shunt		IEA (GO_REF:0000004) with SP_KW:KW-0570	11 others
Cellular Component
cytosol		ISS (PMID:17072883) with SGD:S000002457	2277 others
cytosol		IDA (PMID:16823372)	2277 others
nucleus		IDA (PMID:16823372)	2654 others
Molecular Function
triose-phosphate isomerase activity	heterologous system	IGI (PMID:17072883) with SGD:S000002457	none

Catalytic Activity

EC 5.3.1.1 : IUBMB

Published Expression Profiles

Gene Expression Viewer Cell Cycle

Gene Expression Viewer Meiosis

Gene Expression Viewer Environmental Stress

Gene Expression Viewer Pheromone Response/Mating

TranscriptomeViewer SPCC24B10.21 High-resolution view of transcripts in neighbourhood

Array Express SPCC24B10.21 Array Express Expression profiles

Cyclebase SPCC24B10.21 Cell Cycle Expression Datasets

Literature

Search for tpi1 in PubMed

Protein Families and Domains

View Pfam domain structure for this gene product

View SCOP superfamily

DB	Accs	Description
Pfam	PF00121	Triosephosphate isomerase	(0 Others)
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR000652	Triosephosphate isomerase
PROSITE	PS00171	Triosephosphate isomerase active site.
ProDom	PD001005	ProDom

Database Cross-References

DB	Accs	Description
UniProtKB	P07669	Triosephosphate isomerase (EC 5.3.1.1) (TIM) (Triose-phosphate isomerase).
EMBL	M14432	S.pombe triose-phosphate-isomerase gene, complete cds.
EMBL	CU329672	Schizosaccharomyces pombe chromosome III
EMBL	Z47976	S.pombe gene for mitochondrial DNA polymerase gamma.
BioGrid	SPCC24B10.21	curated genetic and physical interactions
Ensembl	SPCC24B10.21	Ensembl Fungi
NCBI Entrez Gene	SPCC24B10.21	NCBI Entrez Gene
FYSSION	SPCC24B10.21	FYSSION
NBRP	SPCC24B10.21	Fission yeast strain database, National BioResource Project (Japan)
PIR	A23987	PIR
PIR	T50428	PIR
SPD	09/09C02	S. pombe Postgenome Database Orfeome Localization Data
YOGY	SPCC24B10.21	Retrieval of eukaryotic orthologs

UniProtKB Annotation For This Protein

Catalytic Activity

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathway

Carbohydrate biosynthesis; gluconeogenesis. ; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1.

Similarity

Belongs to the triosephosphate isomerase family.

Subunit

Homodimer.

Keywords

Complete proteome (4977 others) , Fatty acid biosynthesis (9 others) , Gluconeogenesis (3 others) , Glycolysis (17 others) , Isomerase (53 others) , Lipid synthesis (31 others) , Pentose shunt (2 others)

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